Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

What determines whether an action is right or wrong? Morality, Rules, and Consequences: A Critical Reader explores for students and researchers the relationship between consequentialist theory and moral rules. Most of the chapters focus on rule consequentialism or on the distinction between act and rule versions of consequentialism. Contributors, among them the leading philosophers in the discipline, suggest ways of assessing whether rule consequentialism could be a satisfactory moral theory. These essays, all of which are previously unpublished, provide students in (...) moral philosophy with essential material and ask key questions on just what the criteria for an adequate moral theory might be. (shrink)

David Émile Durkheim, life and times -- Moral solidarity and the new social science: Durkheim's study of the individual in society and society in the individual -- Morality, law, the state, and politics -- Establishing a social science -- Education as social science and cultural politics -- The "revelation" of religion -- Odds and ends: Durkheim's unfinished works on morality and the family and his war writings -- Further readings.

The 'Art of Life' is John Stuart Mill's name for his account of practical reason. In this volume, eleven leading scholars elucidate this fundamental, but widely neglected, element of Mill's thought. Mill divides the Art of Life into three 'departments': 'Morality, Prudence or Policy, and Æsthetics'. In the volume's first section, Rex Martin, David Weinstein, Ben Eggleston, and Dale E. Miller investigate the relation between the departments of morality and prudence. Their papers ask whether Mill is a rule utilitarian (...) and, if so, whether his practical philosophy must be incoherent. The second section contains papers by Jonathan Riley and Wendy Donner, who explore the relation between the departments of morality and aesthetics. They discuss issues ranging from supererogation to aesthetic pleasure and humanity's relationship with nature. -/- The papers in the third section consider the Art of Life's axiological first principle, the principle of utility. Elijah Millgram contends that Mill's own life refutes his claim that the Art of Life has a single axiological first principle. Philip Kitcher maintains that Mill has a dynamic axiology requiring us to continually refine our conception of the good. In the final section, three papers address what it means to put the Art of Life into practice. Robert Haraldsson locates an 'Art of Ethics' in On Liberty that is in tension with the Art of Life. Nadia Urbinati plumbs the classical roots of Mill's view of the good life. Finally, Colin Heydt develops Mill's suggestion that we regard our own lives as works of art. (shrink)

This excellent collection contains 13 essays from Gadamer's _Kleine Schriften, _dealing with hermeneutical reflection, phenomenology, existential philosophy, and philosophical hermeneutics. Gadamer applies hermeneutical analysis to Heidegger and Husserl's phenomenology, an approach that proves critical and instructive.

Contrary to what many philosophers believe, Calvinism neither makes the problem of evil worse nor is it obviously refuted by the presence of evil and suffering in our world. Or so most of the authors in this book claim. While Calvinism has enjoyed a resurgence in recent years amongst theologians and laypersons, many philosophers have yet to follow suit. The reason seems fairly clear: Calvinism, many think, cannot handle the problem of evil with the same kind of plausibility as other (...) more popular views of the nature of God and the nature of God's relationship with His creation. This book seeks to challenge that untested assumption. With clarity and rigor, this collection of essays seeks to fill a significant hole in the literature on the problem of evil. (shrink)

In his quest to solve 'the ever-disquieting riddle of existence', Schopenhauer explored almost every dimension of human existence, developing a darkly compelling worldview that found deep resonance in contemporary literature, music, philosophy, and psychology. This is the first comprehensive biography of Schopenhauer written in English. Placing him in his historical and philosophical contexts, David E. Cartwright tells the story of Schopenhauer's life to convey the full range of his philosophy. He offers a fully documented portrait in which he explores (...) Schopenhauer's fractured family life, his early formative influences, his critical loyalty to Kant, his personal interactions with Fichte and Goethe, his ambivalent relationship with Schelling, his contempt for Hegel, his struggle to make his philosophy known, and his reaction to his late-arriving fame. (shrink)

Zoos and aquariums have an enormous global reach and hence an ability to craft meaningful conservation action for threatened species, implement educational strategies to encourage human engagement, development and behavior change, and conduct scientific research to enhance the husbandry, roles and impacts of the living collection. The recreational role of the zoo is also vast- people enjoy visiting the zoo and this is often a shared experience amongst family and friends. Evaluating how the zoo influences this “captive audience” and extending (...) its reach to include a compassionate approach to animals and people can further enhance the mission, value, and relevance of their work. The modern zoo’s current aims—Conservation, Education, Research and Recreation—provide useful foundations for the activities that zoos conduct at a local and national level. However, to improve sustainability of their actions and outcomes, we feel that Wellbeing should become the fifth aim of the modern zoo for the future- both from an animal perspective and from a human perspective. This paper provides discussion and review of how Wellbeing is already a substantial part of what zoos work on as well as posing the idea of altering the Recreation aim of the zoo to one of Engagement, which potentially is more measurable and therefore can allow zoo researchers and managers further options for the collection of evidence on the local and global reach of their zoo’s aims. Education, Engagement, Conservation, Research and Wellbeing provide a more complete picture of the roles of the modern zoo for the animals, human visitors and workforce, and to society more widely. (shrink)

We review the major phenomena of skilled typing and propose a model for the control of the hands and fingers during typing. The model is based upon an Activation‐Trigger‐Schema system in which a hierarchical structure of schemata directs the selection of the letters to be typed and, then, controls the hand and finger movements by a cooperative, relaxation algorithm. The interactions of the patterns of activation and inhibition among the schemata determine the temporal ordering for launching the keystrokes. To account (...) for the phenomena of doubling errors, the model has only “type” schemata—no “token” schemata—with only a weak binding between the special schema that signals a doubling, and its argument. The model exists as a working computer simulation and produces an output display of the hands and fingers moving over the keyboard. It reproduces some of the major phenomena of typing, including the interkeystroke interval times, the pattern of transposition errors found in skilled typists, and doubling errors. Although the model is clearly inadequate or wrong in some of its features and assumptions, it serves as a useful first approximation for the understanding of skilled typing. (shrink)

Discussions of “indeterminacy” customarily distinguish two putative types: semantic indeterminacy (SI)—indeterminacy that’s somehow the product of the semantics of our words/concepts—and metaphysical indeterminacy (MI)—indeterminacy that exists as a mind/language-independent feature of reality itself. A popular and influential thought among philosophers is that all indeterminacy must be SI. In this paper we challenge this thought. Our challenge is guided by the question: What, exactly, does it take for a case of indeterminacy to count as SI? We argue that the only satisfactory (...) answer to this question must take SI to be grounded in a more basic type of MI. We conclude that SI cannot be made sense of without implicating MI. If there’s any indeterminacy, there must be indeterminacy in the world itself. (shrink)

We are reporting on how involved the mentor was in promoting responsible research in cases of research misconduct. We reviewed the USPHS misconduct files of the Office of Research Integrity. These files are created by Institutions who prosecute a case of possible research misconduct; ORI has oversight review of these investigations. We explored the role of the mentor in the cases of trainee research misconduct on three specific behaviors that we believe mentors should perform with their trainee: (1) review source (...) data, (2) teach specific research standards and (3) minimize stressful work situations. We found that almost three quarters of the mentors had not reviewed the source data and two thirds had not set standards. These two behaviors are positively correlated. We did not see convincing evidence in the records that mentors were causing stress, but it was apparent in the convicted trainees’ confessions that over 50% experienced some kind of stress. Secondary data, while not created for this research purpose, allows us to look at concrete research behaviors that are otherwise not very researchable. We believe it is important for mentors and institutions to devote more attention to teaching mentors about the process of education and their responsibilities in educating the next generation of scientists. This becomes a critical issue for large research groups who need to determine who is in charge educating, supervising and assuring data integrity. (shrink)

The Psychoanalytic Century examines and celebrates Freuds extraordinary influence on modern analysis and Western culture as a whole. The book comprehensively covers the evolution of our understanding of hysteria as the diagnostic entity through which Freud invented psychoanalysis; and the assessment of the contribution of Freud and his successors to the theory of love and clinical approaches to love relations, as well as to literature, the visual arts, international diplomacy, and race. In this volume we celebrate Freud's legacy, and explore (...) the scope of his impact on psychoanalysis, society, and culture. The contributions of many distinguished colleagues follow the evolution of analysis as his ideas move beyond historical artifact to become living internal objects, embedded in Western culture. David Scharff, from his introduction. (shrink)

David E. Cooper; III*—Anthropology and Translation, Proceedings of the Aristotelian Society, Volume 86, Issue 1, 1 June 1986, Pages 51–68, https://doi.org/10.10.

In order for theology to have a cognitive dimension, it is necessary to have procedures for testing and critically evaluating theological models. We make use of certain features of scientific models to show how science has been able to move beyond the poles of foundationalism, represented by logical positivism, and antifoundationalism or relativism, represented by the sociologists of knowledge. These ideas are generalized to show that constructing and testing theological models similarly offers a means by which theology can move beyond (...) confessionalism and postmodernism. Our starting point is Paul Tillich's concept of God as the ground of being and the different levels of consciousness and thinking that accompany his understanding of theology. The ontological argument of Anselm is shown to play a key role, not as a proof for the existence of God but as a means for testing theological models. An example of a theological model, drawn from the domain of philosophy of science, is presented to show how theological models are constructed and tested. (shrink)

The good news is that our uniquely American formula for research regulation has worked well, on the whole, by placing the first‐line administration of the regulations with peers in the institutions and by minimizing the size of the federal oversight agencies and generally limiting intrusive oversight to serious matters. The bad news has been lack of regulatory coordination, both in the federal government and at research institutions. This is the problem addressed in this supplement in the report by Barbara Bierer (...) and Mark Barnes. (shrink)

Objective Gather information from physicians about factors contributing to unnecessary noninvasive imaging and impact of possible solutions. Methods Qualitative study of 14 physicians using a phenomenological approach and the Theoretical Domains Framework. Results Most participants ( n = 9) self-reported that >10% of the imaging tests they order are unnecessary. External sources of pressure included: peer-review, patient demands, nursing expectations, specialist requests (social demands), as well as prior experience with patient advocates, and the compensation and pension system (environmental context). Internal (...) sources of pressure included reliance on anecdote (emotion), self-doubt about diagnoses (beliefs about capabilities), and fear of missing a diagnosis and of professional liability (beliefs about consequences). Participants expressed both optimism and concern about potential solutions, such as adopting decision support software. Conclusion Physicians are under pressure from multiple sources to order unnecessary imaging. Peer review, nursing expectations, and perceptions about Veteran compensation and pension are newly reported contributing factors. (shrink)

A strong parallel exists between current research methodologies in the social sciences and the two most central and popular approaches to aesthetics over the last four centuries. The point of this paper is to show this parallel, to demonstrate the importance and relevance of this parallel, and finally to examine ways of deciding, given this parallel between research methodologies and aesthetic approaches, which research methodology in a given context is the better.

Barbey & Sloman (B&S) relegate the logical rule of the excluded middle to a footnote. But this logical rule is necessary for natural sampling. Making the rule explicit in a logical tree can make a problem easier to solve. Examples are given of uses of the rule that are non-constructive and not reducible to a domain-specific module.

This commentary argues against the indictment of current experimental practices such as piecemeal testing, and the proposed integrated experiment design (IED) approach, which we see as yet another attempt at automating scientific thinking. We identify a number of undesirable features of IED that lead us to believe that its broad application will hinder scientific progress.

This paper argues that due to considerations of proximity of particular humans to particular (nonhuman) animals, and to the impact this proximity has on the obligations felt by those humans to those animals, an animal rights strategy as a means of specifying what obligations humans really do have toward animals cannot be successful. The good news, however; is that it is out of these proximity relations that we can begin to understand just what obligations humans properly do have toward animals.

Teases out from assumptions underlying Polybius's constitutional theory an otherwise unknown subjectivist, agent-relative utilitarian theory of well-being. In contrast to other ancient theories, other-concern is assumed to be rooted in nonrational human nature and without moral value. Moral concepts arise within a social community from rational reflection on personal experience and lead to socially constructed moral values and political institutions that promote cooperative over competitive behaviors. The assumptions meet Arcesilaus's skeptical objections to dogmatic ethics. Polybius, some of whose political associates (...) studied under Arcesilaus, may have derived his theory from current antiskeptical justifications of normative ethics and politics. (shrink)

Not long after the historian, Seeley, had defined ‘perfect liberty’ as ‘the absence of all government’, Oscar Wilde wrote that a man can be totally free even in that granite embodiment of governmental constraint, prison. Ten years after Mill's famous defence of civil freedoms, On Liberty, Richard Wagner declaimed:I'll put up with everything—police, soldiers, muzzling of the press, limits on parliament… Freedom of the spiriti is the only thing for men to be proud of and which raises them above animals.

Resumen El artículo muestra la relación estructural entre el testimonio y el juicio estético, y cómo la mentira estructural se implica irreductiblemente como la posibilidad de la verdad. Se explica la necesaria imposibilidad del testimonio como condición de su posibilidad, argumento anticipado por J. L. Borges: “No hay una sola hermosa palabra, con la excepción dudosa de testigo, que no sea una abstracción”. La argumentación se apoya en la teoría husserliana del syncategorema y en los deícticos ; asimismo, se toma (...) de I. Kant el papel de la imaginación y los efectos del “como si”.This essay demonstrates the structural relationship between testimony and aesthetic judgment. The implications of this discovery are several, the most important being the relationship between the lie and truth, implicating that lie indicates the irreducible possibility of truth. The essay explains the necessary impossibility of the testimony as a condition of its possibility, an argument anticipated in Jorge Luis Borges’ beautiful phrase, “There is not a single beautiful word, with the dubious exception of witness, that is not an abstraction”. The argument is based on Husserl’s theory of the syncategorem and on deictic words ; as well, it takes from Kant, the role of the imagination and the effects of the “as if”. (shrink)

Our aim in this paper was to establish an empirical evaluation for similarity effects modeled by Rubinstein; Azipurua et al.; Leland; and Sileo. These tests are conducted through a sensitivity analysis of two well-known examples of expected utility (EU) independence violations. We found that subjective similarity reported by respondents was explained very well by objective measures suggested in the similarity literature. The empirical results of this analysis also show that: (1) the likelihood of selection for the riskier choice increases as (...) the pair becomes more similar, (2) these choice patterns are consistent with well-known independence violations of expected utility, and (3) a significant proportion of individuals exhibit intransitive choice patterns predicted under similarity effects, but not allowed under generalized expected utility models for risky choice. (shrink)